Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native (porcine) and cloned (human) 5-HT2C receptors). 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Agomelatine hydrochloride 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 233 | 5日内发货 | ||
5 mg | ¥ 378 | 5日内发货 | ||
10 mg | ¥ 645 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 418 | 5日内发货 |
Agomelatine (L(+)-Tartaric acid) 的其他形式现货产品:
产品描述 | Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native (porcine) and cloned (human) 5-HT2C receptors). |
靶点活性 | HEK-hMT1:0.06 nM (ki), 5-HT2C receptor (human):6.2 pki, 5-HT2C receptor (native porcine): pki: 6.4 , HEK-hMT2:0.27 nM (ki), MT2 (human, CHO cells):0.12 nM (ki), MT1 (human, CHO cells):ki:0.1 nM |
体外活性 | Agomelatine acts as a full agonist of MT1 and MT2 receptors with EC50s of 1.6, 0.10 nM for CHO hMT1 CHO-hMT2 (hΜΤ1 and hΜΤ2 receptors expressed in CHO or HEK cell membranes) [1]. Agomelatine also interacts with h5-HT2B receptors, whereas it shows low affinity at native (rat)/cloned, human 5-HT2A (<5.0/5.3), and 5-HT1A (<5.0/5.2) receptors, and negligible (<5.0) affinity for other 5-HT receptors [2]. |
体内活性 | Agomelatine (25, 50, or 75 mg/kg; i.p.) has antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice. Agomelatine does not have any antioxidant effects on parameters of oxidative stress produced by Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models when compared to controls [3]. |
别名 | 阿戈美拉汀 L(+)-酒石酸, S-20098 L(+)-Tartaric acid |
分子量 | 393.39 |
分子式 | C19H23NO8 |
CAS No. | 824393-18-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Agomelatine (L(+)-Tartaric acid) 824393-18-2 GPCR/G Protein Neuroscience 5-HT Receptor 阿戈美拉汀 L(+)-酒石酸 S-20098 L(+)-Tartaric acid Agomelatine (L(+)Tartaric acid) Agomelatine (L(+) Tartaric acid) S-20098 LTartaric acid Agomelatine (LTartaric acid) Inhibitor inhibitor inhibit